2H-Tetrazole, 5-(2-iodophenyl)-

2H-Tetrazole, 5-(2-iodophenyl)- - Names and Identifiers

Name	5-(2-Iodophenyl)-1H-tetrazole
Synonyms	5-(2-IODOPHENYL)-1H-TETRAZOLE 5-(2-iodophenyl)-2H-tetrazole 5-(2-Iodophenyl)-1H-tetrazole 1H-tetrazole, 5-(2-iodophenyl)- 2H-Tetrazole, 5-(2-iodophenyl)- 2-IPT 1H-Tetrazole,5-(2-iodophenyl) 5-(2-IODOPHENYL)-1H-TETRAZOLE TRITYL DERIVATIVE IS ALSO AVAILABLE
CAS	73096-40-9
InChI	InChI=1/C7H5IN4/c8-6-4-2-1-3-5(6)7-9-11-12-10-7/h1-4H,(H,9,10,11,12)

2H-Tetrazole, 5-(2-iodophenyl)- - Physico-chemical Properties

Molecular Formula	C7H5IN4
Molar Mass	272.05
Density	2.018g/cm³
Boling Point	403.187°C at 760 mmHg
Flash Point	197.64°C
Vapor Presure	0mmHg at 25°C
Storage Condition	2-8℃
Refractive Index	1.706
MDL	MFCD07779116

2H-Tetrazole, 5-(2-iodophenyl)- - Introduction

5-(2-Iodophenyl)-1H-tetrazole is an organic compound with the molecular formula C7H4IN5. The following is its nature, use, preparation and safety information:

Nature:
-Appearance: 5-(2-Iodophenyl)-1H-tetrazole is a white crystal or light yellow solid.
-Melting point: about 220-223 ℃.
-Stability: relatively stable at room temperature, but may decompose in the presence of strong acid or strong base.

Use:
-Medicinal Chemistry: 5-(2-Iodophenyl)-1H-tetrazole is an important intermediate for the synthesis of drugs and bioactive molecules. It is commonly used in the preparation of various biologically active compounds, such as drugs, biomarkers, pesticides, etc.

Preparation Method:
- 5-(2-Iodophenyl)-1H-tetrazole is usually synthesized by a three-step reaction:
1.2-iodobenzeneborate is obtained by reacting 2-iodobenzeneborate with 2-iodobenzeneborate.
2. The tetrazole ring is introduced by the reaction of sodium azide and trifluoroacetic acid to generate 2-iodophenyl -1H-tetrazole.
3. Hydrogenation of 2-iodophenyl-1H-tetrazole to give the final product 5-(2-iodophenyl)-1H-tetrazole.

Safety Information:
-Use with care to avoid inhalation, swallowing or contact with skin and eyes.
-Wear appropriate protective equipment such as glasses, gloves and lab coats during use.
- 5-(2-Iodophenyl)-1H-tetrazole should be stored in a dry, well-ventilated place, away from ignition and strong oxidants.
-If exposed to this compound, immediately flush the affected area with plenty of water and seek medical assistance.

Last Update：2024-04-09 02:00:47